Clinical research found that Sativex is very effective for treating neuropathic pain in multiple sclerosis (MS) patients, and this medication is available for MS patients in Canada.
Studies That Confirm The Effectiveness of a CBD-Containing Drug
During this study from 2006, patients with multiple sclerosis were given Sativex in the form of a spray, and researchers found that 8-12 sprays per day significantly diminished symptoms of MS, most notably neuropathic pain and muscle spasticity.
Researchers concluded that “Sativex is efficacious and well tolerated in the treatment of these symptoms”.
Researchers in a different study from 2007 summarized the efficacy and safety profile of Sativex for MS patients suffering from neuropathic pain, agreeing that cannabinoid-based medications are helpful:
“Cannabinoids including the cannabidiol/THC buccal spray are effective in treating neuropathic pain in MS.”
Finally, a 2008 study concurred that Sativex is beneficial for various types of pain:
“Numerous randomized clinical trials have demonstrated safety and efficacy for Sativex in central and peripheral neuropathic pain, rheumatoid arthritis and cancer pain.”
Even though the aforementioned studies were focusing on the effects of CBD and THC used together, there are several studies that indicate that the use of CBD alone can prove beneficial for various types of pain.
This 2012 research mentioned that the use of CBD significantly suppressed both neuropathic pain and chronic inflammation in rodents, without causing any apparent analgesic tolerance.
A review from 2013 noted that orally-ingested CBD appears to be a promising compound for the treatment of chronic inflammation and neuropathic pain.
Conclusively, a 2018 scientific review mentioned that cannabidiol (CBD) is a very important chemical compound that may possess “significant analgesic, anti-inflammatory, anticonvulsant and anxiolytic activities.”
Besides the sensation of neural pain, sciatica is often accompanied with inflammation.
Multiple studies are showing that CBD directly lowers inflammation:
How to Use CBD for Sciatica
There are three different methods of administration for sciatica, and they include:
Oils and topicals require about 15 minutes to start working, while capsules require 60~90 minutes.
CBD Dosage for Sciatica
A single dose in the range of 15 mg to 20 mg of CBD is usually adequate to relieve symptoms for most users, while some users require larger doses (40 mg or 60 mg).
Some people don’t experience any beneficial effects when they start using CBD. This isn’t completely understood, but a contemporary scientific hypothesis (called clinical endocannabinoid system deficiency) attempts to explain this occurrence.
This theory mentions that some people have a dysfunctional endocannabinoid system, which is an internal bodily system through which CBD creates the majority of its effects.
A dysfunctional endocannabinoid system makes CBD therapy somewhat difficult, but certainly not impossible.
Clinical endocannabinoid system deficiency hypothesis explains that a frequent exposure to cannabinoids like CBD progressively revitalizes the endocannabinoid system.
If you don’t experience any beneficial effects, continue using CBD on a daily basis to “restart” your endocannabinoid system. This process usually requires several weeks.
Possible Side Effects of CBD & Drug Interactions
While most users don’t experience any issues during their CBD treatment, a small percentage of consumers can experience side effects.
Reasons to why this occurs are still unclear, but a running hypothesis is that age, overall health and personal genetics of the user affect how they react to the treatment.
The main potential side effects of CBD include nausea, diarrhea, changes in body weight and appetite, and users who take large daily doses may also feel irritability and fatigue.
Another important aspect of CBD therapy is how this compound interacts with other drugs.
It’s crucial to note that products containing CBD can interfere with the metabolization (breakdown) of drugs that have a grapefruit warning on their packaging.
This occurs because CBD is metabolized by the same enzyme as those drugs, and that enzyme is called CYP3A4.
If a user consumes two (or more) substances at the same time that are metabolized by the same enzyme, the enzyme can have a hard time metabolizing all those substances at once.
Elevated levels of an unmetabolized drug in the body are potentially hazardous, and should definitely be avoided.