Hashish sativa L. preparations have been utilized in medication for millenia. Nonetheless, concern over the risks of abuse led to the banning of the medicinal use of marijuana in most international locations within the 1930s. Solely lately, marijuana and particular person pure and artificial cannabinoid receptor agonists and antagonists, in addition to chemically associated compounds, whose mechanism of motion remains to be obscure, have come again to being thought-about of therapeutic worth. Nonetheless, their use is very restricted. Regardless of the gentle habit to cannabis and the potential enhancement of habit to different substances of abuse, when mixed with cannabis, the therapeutic worth of cannabinoids is simply too excessive to be put apart. Quite a few illnesses, akin to anorexia, emesis, ache, irritation, a number of sclerosis, neurodegenerative problems (Parkinson’s illness, Huntington’s illness, Tourette’s syndrome, Alzheimer’s illness), epilepsy, glaucoma, osteoporosis, schizophrenia, cardiovascular problems, most cancers, weight problems, and metabolic syndrome-related problems, to call only a few, are being handled or have the potential to be handled by cannabinoid agonists/antagonists/cannabinoid-related compounds. In view of the very low toxicity and the widely benign uncomfortable side effects of this group of compounds, neglecting or denying their medical potential is unacceptable–as a substitute, we have to work on the event of extra selective cannabinoid receptor agonists/antagonists and associated compounds, in addition to on novel medicine of this household with higher selectivity, distribution patterns, and pharmacokinetics, and–in instances the place it’s not possible to separate the specified medical motion and the psychoactivity–simply to watch these uncomfortable side effects fastidiously.