The endocannabinoid system (ECS) is an in depth endogenous signaling system with a number of components, the variety of which can be rising as scientists proceed to elucidate its function in human well being and illness. The ECS is seemingly ubiquitous in animal species and is modulated by weight loss program, sleep, train, stress, and a mess of different elements, together with publicity to phytocannabinoids, like Cannabidiol ( CBD). Modulating the exercise of this method could supply large therapeutic promise for a various scope of ailments, starting from psychological well being issues, neurological and motion issues, ache, autoimmune illness, spinal wire harm, most cancers, cardiometabolic illness, stroke, TBI, osteoporosis, and others.